beta-Secretase Inhibitor IV

Description: beta-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1, with IC50 values of 15.6 nM and 16.3 nM at BACE-1 concentrations of 2 nM and 100 pM, respectively. Target: Others. Smiles: C(N[C@@H](CC1=CC=CC=C1)[C@@H](CNC2CC2)O)(=O)C3=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=CC(N(S(C)(=O)=O)C)=C3. References: Pietrak BL, et al. Biochemical and cell-based assays for characterization of BACE-1 inhibitors. Anal Biochem. 2005 Jul 1,342(1):144-51.