beta-Nicotinamide Mononucleotide

beta-Nicotinamide mononucleotide (beta-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+, Cay-16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate beta-NMN, which is subsequently converted to NAD+ by beta-NMN adenyltransferase. At 50-100 µM, beta-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in beta cell function. Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.Formal Name: 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-pyridinium, inner salt. CAS Number: 1094-61-7. Synonyms: beta-NMN. Molecular Formula: C11H15N2O8P. Formula Weight: 334.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 210, 265 nm. SMILES: O[C@H]1[C@@H](O)[C@H]([N+]2=CC(C(N)=O)=CC=C2)O[C@@H]1COP(O)([O-])=O. InChi Code: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1. InChi Key: DAYLJWODMCOQEW-TURQNECASA-N.