beta-NETA

Description: beta-NETA (alpha-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 µM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. beta-NETA has anti-cancer activity[1][2]. beta-NETA weakly inhibits cholinesterase (IC50=84 µM) and acetylcholinesterase (IC50=300 µM). Target: AChE. Smiles: [I-].C[N+](C)(C)CCC(=O)c1ccc2ccccc2c1. References: Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep,20(9):751-71.