beta-Lapachone

beta-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 µM and transglutaminase (IC50 = 5 µM). In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, beta-lapachone is reduced to beta-lapachone hydroquinone, which generates reactive oxygen species during its reversion to beta-lapachone. This process sensitizes cancer cells to radiation, suppresses NF-kappaB activation, and drives apoptosis.Formal Name: 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione. CAS Number: 4707-32-8. Synonyms: ARQ 501, NSC 26326, NSC 629749, SL 11001. Molecular Formula: C15H14O3. Formula Weight: 242.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml, DMSO: 5 mg/ml, Ethanol: 3.3 mg/ml. lambdamax: 213, 256, 263, 279 nm. SMILES: O=C(C1=C(C2=C3CCC(C)(C)O2)C=CC=C1)C3=O. InChi Code: InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3. InChi Key: QZPQTZZNNJUOLS-UHFFFAOYSA-N.