Bepotastine

Bepotastine is an antagonist of the histamine H1 receptor that is selective over H3, alpha1-, alpha2-, and beta-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors. It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED50 = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg). Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner. Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.Formal Name: 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid. CAS Number: 125602-71-3. Molecular Formula: C21H25ClN2O3. Formula Weight: 388.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble, Water: Soluble. SMILES: ClC1=CC=C(C=C1)[C@@H](C2=CC=CC=N2)OC(CC3)CCN3CCCC(O)=O. InChi Code: InChI=1S/C21H25ClN2O3/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26)/t21-/m0/s1. InChi Key: YWGDOWXRIALTES-NRFANRHFSA-N.