Benproperine (phosphate)

Benproperine is an antitussive agent and actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. It increases the latency to first cough and decreases the number of coughs during and after a citric acid aerosol challenge in a guinea pig model of cough when administered at a dose of 27 mg/kg. It binds to ARPC2 and delays the initiation of actin polymerization in the presence of actin, the Arp2/3 complex, and the Wiskott-Aldrich syndrome protein (WASP) VCA domain, but not actin alone, when used at a concentration of 10 µM. Benproperine (1-10 µM) inhibits the migration and invasion of DLD-1 and AsPC-1 cancer cells and reduces lung metastasis in an AsPC-1 mouse model of metastasis when administered at a dose of 50 m/kg. Formulations containing benproperine have been used as cough suppressants.Formal Name: 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-piperidine, monophosphate. CAS Number: 19428-14-9. Synonyms: ASA 158-5, BPP. Molecular Formula: C21H27NO . H3PO4. Formula Weight: 407.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: insol, Ethanol: insol, PBS (pH 7.2): 1 mg/ml. SMILES: O=P(O)(O)O.CC(N1CCCCC1)COC2=CC=CC=C2CC3=CC=CC=C3. InChi Code: InChI=1S/C21H27NO.H3O4P/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19,1-5(2,3)4/h2,4-7,10-13,18H,3,8-9,14-17H2,1H3,(H3,1,2,3,4). InChi Key: MCVUURBOSHQXMK-UHFFFAOYSA-N.