Belizatinib

Belizatinib is an inhibitor of anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases A/B/C (IC50s = 0.7 and <3 nM, respectively).Formal Name: 4-fluoro-N-[6-[[4-(1-hydroxy-1-methylethyl)-1-piperidinyl]methyl]-1-[cis-4-[[(1-methylethyl)amino]carbonyl]cyclohexyl]-1H-benzimidazol-2-yl]-benzamide. CAS Number: 1357920-84-3. Synonyms: TSR-011. Molecular Formula: C33H44FN5O3. Formula Weight: 577.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 324 nm. SMILES: CC(C)(O)C(CC1)CCN1CC2=CC=C(N=C(NC(C3=CC=C(F)C=C3)=O)N4[C@]5([H])CC[C@H](C(NC(C)C)=O)CC5)C4=C2. InChi Code: InChI=1S/C33H44FN5O3/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)/t24-,27+. InChi Key: WSTUJEXAPHIEIM-FEGDYQJNSA-N.