BDW568

BDW568 is an agonist of stimulator of interferon genes (STING) and a prodrug form of BDW-OH. It induces STING transcriptional activity in a reporter assay using THP-1 cells (EC50 = 7.6 µM). BDW568 (50 µM) induces phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) in THP-1 cells.Formal Name: 2-[(8,9-dimethylthieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-yl)thio]-acetic acid, methyl ester. CAS Number: 335401-44-0. Molecular Formula: C12H12N4O2S2. Formula Weight: 308.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, Chloroform: Soluble, Methanol: Soluble. SMILES: O=C(OC)CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3. InChi Code: InChI=1S/C12H12N4O2S2/c1-6-7(2)20-11-9(6)10-14-15-12(16(10)5-13-11)19-4-8(17)18-3/h5H,4H2,1-3H3. InChi Key: RNNRGNUAQCUYEG-UHFFFAOYSA-N.