Balsalazide

Balsalazide is a prodrug form of 5-aminosalicylic acid (5-ASA, Cay-70265). It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB). Formulations containing balsalazide have been used in the treatment of ulcerative colitis.Formal Name: 5-[(1E)-2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]diazenyl]-2-hydroxy-benzoic acid. CAS Number: 80573-04-2. Molecular Formula: C17H15N3O6. Formula Weight: 357.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 263, 364 nm. SMILES: OC1=CC=C(/N=N/C2=CC=C(C(NCCC(O)=O)=O)C=C2)C=C1C(O)=O. InChi Code: InChI=1S/C17H15N3O6/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26)/b20-19+. InChi Key: IPOKCKJONYRRHP-FMQUCBEESA-N.