Balovaptan

Description: Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors. It is used for the research of autism. Target: Vasopressin Receptor. Smiles: [H][C@@]1(CC[C@@H](CC1)Oc1ccccn1)c1nnc2CN(C)Cc3cc(Cl)ccc3-n12. References: Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12,58(5):2275-89.