Bafilomycin A1

Description: Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis. Target: Antibacterial, Apoptosis, Autophagy, Antibiotic, Proton pump. Smiles: [H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C. References: Ohta T, et al. Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-J Pathol. 1998 Jul,185(3):324-30.