B-973B

B-973B is an allosteric agonist and positive allosteric modulator (ago-PAM) of alpha7 nicotinic acetylcholine receptors (nAChRs). It enhances ACh-induced activation in a two-electrode voltage-clamp assay using Xenopus oocytes expressing the human alpha7 nAChR when used at a concentration of 10 µM. B-973B (10 mg/kg) decreases paw edema and induces antinociception in the first and second phase of the formalin test in a mouse model of inflammatory pain. It also inhibits tau aggregation induced by seeding with insoluble human tau isolated from a patient with Alzheimer's disease in primary rat neurons in a concentration-dependent manner.Formal Name: 3,4-difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]-benzenepropanamide. CAS Number: 2244989-34-0. Synonyms: (-)-(S)-B-973B. Molecular Formula: C24H26F2N6O. Formula Weight: 452.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: FC(C=C1CCC(N[C@H](C2=CN=CC(N3CCN(C4=CC=CC=N4)CC3)=N2)C)=O)=C(C=C1)F. InChi Code: InChI=1S/C24H26F2N6O/c1-17(29-24(33)8-6-18-5-7-19(25)20(26)14-18)21-15-27-16-23(30-21)32-12-10-31(11-13-32)22-4-2-3-9-28-22/h2-5,7,9,14-17H,6,8,10-13H2,1H3,(H,29,33)/t17-/m0/s1. InChi Key: WQYZERNSONBUCW-KRWDZBQOSA-N.