AZD 7325

AZD 7325 is a positive allosteric modulator of alpha2- and alpha3 subunit-containing GABAA receptors and a neutral antagonist for alpha1 subunit-containing GABAA receptors. It binds to GABAA receptors in membranes from Sf9 cells expressing alpha2beta3gamma2 subunit-containing receptors (Ki = 0.309 nM). AZD 7325 (1 mg/kg) increases marble-burying behavior, indicating anxiety-like activity, and decreases audiogenic seizure severity in the Fmr1-/- mouse model of fragile X syndrome.Formal Name: 4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propyl-3-cinnolinecarboxamide. CAS Number: 942437-37-8. Synonyms: BAER-101. Molecular Formula: C19H19FN4O2. Formula Weight: 354.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 220, 345 nm. SMILES: O=C(C1=C(N)C2=CC=CC(C3=C(OC)C=CC=C3F)=C2N=N1)NCCC. InChi Code: InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25). InChi Key: KYDURMHFWXCKMW-UHFFFAOYSA-N.