AZD 5438

AZD 5438 is a potent inhibitor of the cyclin-dependent kinases (CDKs) 1, 2, and 9 (IC50s = 16, 6, and 20 nM, respectively). AZD 5438 also inhibits the kinase activity of Cdk5/p25 and glycogen synthase kinase 3beta (GSK3beta) (IC50s = 14 and 17 nM, respectively). AZD 5438 induces cell cycle arrest by inhibiting phosphorylation of CDK-dependent substrates and exhibits in vitro antiproliferative activity against a range of tumor cell lines including lung, colorectal, breast, prostate, and hematologic tumors with IC50s ranging from 200 nM (MCF-7) to 1,700 nM (ARH-77). AZD 5438 inhibits growth of human tumor xenografts derived from a wide range of cancer types and inhibits cell cycle proteins.Formal Name: 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine. CAS Number: 602306-29-6. Molecular Formula: C18H21N5O2S. Formula Weight: 371.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 300 nm. SMILES: CS(C1=CC=C(NC2=NC(C3=CN=C(C)N3C(C)C)=CC=N2)C=C1)(=O)=O. InChi Code: InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22). InChi Key: WJRRGYBTGDJBFX-UHFFFAOYSA-N.