AZD 5305

AZD 5305 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 0.003 µM). It is selective for PARP1 over PARP2, PARP3, PARP5a, and PARP6 (IC50s = 1.4, 3.4, >89, and 26 µM, respectively). AZD 5305 inhibits the proliferation of BRCA2-/- DLD-1 colorectal cancer cells (IC50 = 0.002 µM). It induces tumor regression in a patient-derived xenograft (PDX) mouse model of BRCA1 mutant triple-negative breast cancer (TNBC) when administered at doses ranging from 0.3 to 10 mg/kg.Formal Name: 5-[4-[(7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide. CAS Number: 2589531-76-8. Molecular Formula: C22H26N6O2. Formula Weight: 406.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.5 mg/ml, DMSO: 0.1 mg/ml. lambdamax: 222, 330 nm. SMILES: O=C(C1=NC=C(N2CCN(CC2)CC3=CC4=C(C=C(CC)C(N4)=O)N=C3)C=C1)NC. InChi Code: InChI=1S/C22H26N6O2/c1-3-16-11-19-20(26-21(16)29)10-15(12-24-19)14-27-6-8-28(9-7-27)17-4-5-18(25-13-17)22(30)23-2/h4-5,10-13H,3,6-9,14H2,1-2H3,(H,23,30)(H,26,29). InChi Key: WQAVGRAETZEADU-UHFFFAOYSA-N.