AZD 2932

AZD 2932 is an inhibitor of VEGFR2, PDGFRbeta, CSF1R, c-KIT, and FLT3 receptor tyrosine kinases (IC50s = 4, 8, 100, 9, and 7 nM, respectively). It also inhibits Pdgfralpha phosphorylation (IC50 = 2 nM) in lysates from C6 rat glial tumors grown in athymic mice. AZD 2932 (12.5-50 mg/kg) reduces tumor growth and inhibits Pdgfrbeta and Vegfr2 phosphorylation in a 1:1 ratio in a C6 mouse xenograft model. Xenograft models using non-PDGFR expressing tumor cells were insensitive to AZD 2932 treatment.Formal Name: 4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-benzeneacetamide. CAS Number: 883986-34-3. Molecular Formula: C24H25N5O4. Formula Weight: 447.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMSO: 0.25 mg/ml. lambdamax: 239, 320 nm. SMILES: COC1=CC2=C(C(OC3=CC=C(CC(NC4=CN(C(C)C)N=C4)=O)C=C3)=NC=N2)C=C1OC. InChi Code: InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30). InChi Key: TWYCZJMOEMMCGC-UHFFFAOYSA-N.