AZD 2716

AZD 2716 is an inhibitor of secretory phospholipase A2 (sPLA2, IC50s = 0.01, 0.04, and 0.4 µM for sPLA2-IIa, -V, and -X, respectively). It inhibits sPLA2 activity in atherosclerotic plaque homogenates isolated from patients with coronary artery disease (IC50 = 56 nM).Formal Name: (alphaR)-2'-(aminocarbonyl)-alpha-methyl-5'-(phenylmethyl)-[1,1'-biphenyl]-3-propanoic acid. CAS Number: 1845753-81-2. Molecular Formula: C24H23NO3. Formula Weight: 373.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 16 mg/ml, DMSO: 10 mg/ml, Ethanol: 16 mg/ml, PBS (pH 7.2): 0.3 mg/ml. SMILES: NC(C1=C(C2=CC(C[C@@H](C)C(O)=O)=CC=C2)C=C(C=C1)CC3=CC=CC=C3)=O. InChi Code: InChI=1S/C24H23NO3/c1-16(24(27)28)12-18-8-5-9-20(14-18)22-15-19(10-11-21(22)23(25)26)13-17-6-3-2-4-7-17/h2-11,14-16H,12-13H2,1H3,(H2,25,26)(H,27,28)/t16-/m1/s1. InChi Key: PXRCDPVYRPKGGI-MRXNPFEDSA-N.