AZD 1208

AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively). It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice. It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110alpha inhibitors, respectively.Formal Name: (5Z)-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione. CAS Number: 1204144-28-4. Molecular Formula: C21H21N3O2S. Formula Weight: 379.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 230, 327 nm. SMILES: O=C(N1)S/C(C1=O)=C\C2=C(N3CCC[C@@H](N)C3)C(C4=CC=CC=C4)=CC=C2. InChi Code: InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1. InChi Key: MCUJKPPARUPFJM-UWCCDQBKSA-N.