AZD 0156

AZD 0156 is an inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50s = 0.04 and 0.57 nM in enzyme and cell-based assays, respectively). It is selective for ATM over other PI3K-related kinase (PIKK) family kinases including DNA-PK, mTOR, PI3Kalpha, PI3Kbeta, PI3Kgamma, and PI3Kdelta (IC50s = 0.14, 0.20, 0.32, 1.8, 1.1, and 0.27 µM, respectively, in enzyme assays). AZD 0156 (20 mg/kg) enhances the antitumor activity of irinotecan (Cay-14180) in an SW620 colon cancer mouse xenograft model and olaparib (Cay-10621) in an HBCx-10 breast cancer patient-derived xenograft (PDX) mouse model when administered at a dose of 5 mg/kg, leading to tumor regression in both models.Formal Name: 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-2H-imidazo[4,5-c]quinolin-2-one. CAS Number: 1821428-35-6. Molecular Formula: C26H31N5O3. Formula Weight: 461.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 210, 273 nm. SMILES: CN(C)CCCOC(C=C1)=NC=C1C2=CC3=C(C=C2)N=CC4=C3N(C5CCOCC5)C(N4C)=O. InChi Code: InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3. InChi Key: AOTRIQLYUAFVSC-UHFFFAOYSA-N.