AZ7550

Description: AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 µM). Target: ALK, BTK, MLK, IGF-1R, ACK, EGFR, FLT, Drug Metabolite, MNK, Tyrosine Kinases, FAK, PYK2. Smiles: CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCNC)C)C(NC(C=C)=O)=C4)=NC=C3. References: Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23,57(20):8249-67.