AY 9944

Description: AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Delta7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Delta7-Delta8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3beta-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC. Target: Others. Smiles: Cl.Cl.Clc1ccccc1CNC[C@H]1CC[C@H](CNCc2ccccc2Cl)CC1. References: Dvornik D, et al. Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol delta 7-reductase, on serum and tissue lipids in the rat. J Lipid Res. 1968 Sep,9(5):587-95.