Axitinib Sulfoxide

Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib (Cay-13813). It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.Formal Name: N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide. CAS Number: 1347304-18-0. Molecular Formula: C22H18N4O2S. Formula Weight: 402.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(NC)C1=C(S(C2=CC3=C(C(/C=C/C4=NC=CC=C4)=NN3)C=C2)=O)C=CC=C1. InChi Code: InChI=1S/C22H18N4O2S/c1-23-22(27)18-7-2-3-8-21(18)29(28)16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+. InChi Key: MAHSNFBPPYMWFB-FMIVXFBMSA-N.