AX-024 hydrochloride

Description: AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNFalpha), interferon-gamma (IFN-gamma), IL-10 and IL-17A. Target: COX, Interleukin, IFNAR, TNF, IL Receptor. Smiles: Cl.COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1. References: Borroto A, etal. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21,8(370):370ra184.