AUY-954 free base

Description: AUY-954 is an effective selective S1P(1) modulator. It can significantly reduce the local expression of EAN rat sciatic nerve T cells, B cells, macrophage infiltration, inflammatory demyelination, interleukin-17 and matrix metalloproteinase-9. Target: Others. Smiles: C(F)(F)(F)C1=C(C=CC(=C1)C2=CC=3C(S2)=CC=C(CNCCC(O)=O)C3)C4=CC=CC=C4. References: Montrose DC, Scherl EJ, Bosworth BP, Zhou XK, Jung B, Dannenberg AJ, Hla T. S1P1 localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. J Lipid Res. 2013 Mar,54(3):843-51. doi: 10.1194/jlr.M034108. Epub 2013 Jan 7. PubMed PMID: 23296878, PubMed Central PMCID: PMC3617958.