Atpenin A5

Atpenin A5
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay11898-1 1 mg -

6 - 10 Werktage*

321,00 €
 
Mitochondrial complex II (succinate dehydrogenase or succinate:ubiquinone oxidoreductase) is a... mehr
Produktinformationen "Atpenin A5"
Mitochondrial complex II (succinate dehydrogenase or succinate:ubiquinone oxidoreductase) is a functional member of the Krebs cycle and the aerobic respiratory chain that couples the oxidation of succinate to fumarate with the reduction of quinone to quinol. Atpenin A5, an antifungal antibiotic isolated from Penicillium sp. found in soil, is a highly specific ubiquinone-binding site inhibitor of succinate dehydrogenase (IC50s = 12 and 3.7 nM in nematode and mammalian mitochondria, respectively, versus IC50s > 100 µM for inhibition of complex I and complex III enzymes). Atpenin A5 has cardioprotective effects against simulated ischemia-reperfusion injury in cardiomyocytes. Several mechanisms through which this occurs, including activation of mitochondrial ATP-sensitive potassium channels or modulation of mitochondrial reactive oxygen species generation, have been proposed.Formal Name: 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone. CAS Number: 119509-24-9. Synonyms: Antibiotic FO-125A5. Molecular Formula: C15H21Cl2NO5. Formula Weight: 366.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. lambdamax: 237, 272, 324 nm. SMILES: COC(NC(O)=C1C([C@H](C[C@H](C)[C@H](CCl)Cl)C)=O)=C(OC)C1=O. InChi Code: InChI=1S/C15H21Cl2NO5/c1-7(9(17)6-16)5-8(2)11(19)10-12(20)13(22-3)15(23-4)18-14(10)21/h7-9H,5-6H2,1-4H3,(H2,18,20,21)/t7-,8-,9-/m0/s1. InChi Key: OVULNOOPECCZRG-CIUDSAMLSA-N. Origin: Synthetic, originally from fungal strain FO-125.
Schlagworte: Antibiotic FO-125A5, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone
Hersteller: Cayman Chemical
Hersteller-Nr: 11898

Eigenschaften

Anwendung: Succinate-ubiquinone oxidoreductase inhibitor
MW: 366.2 D
Formel: C15H21Cl2NO5
Reinheit: >95%
Format: Crystalline Solid

Datenbank Information

CAS : 119509-24-9| Passende Produkte
KEGG ID : K00234 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H301, H311, H330
P-Sätze: P260, P264, P270, P271, P280, P284, P312, P320, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P405, P403+P233, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Atpenin A5"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen