Asperuloside

Asperuloside is an iridoid glycoside that has been found in G. tunetanum and has diverse biological activities, including anti-angiogenic, anti-inflammatory, and anti-obesity properties. It reduces microvessel formation by 67% in a chick embryo chorioallantoic membrane assay when used at a concentration of 2 µg/egg. Asperuloside (20, 40, and 80 mg/L) inhibits LPS-induced increases in TNF-alpha, IL-1beta, and IL-6 production in RAW 264.7 macrophages in a concentration-dependent manner. It reduces lung myeloperoxidase (MPO) activity and bronchoalveolar lavage fluid (BALF) levels of TNF-alpha, IL-1beta, and IL-6 in a mouse model of LPS-induced acute lung injury when administered at doses of 20, 40, and 80 mg/kg. Dietary administration of asperuloside decreases body weight gain, white adipose tissue (WAT) weight, and the ratio of WAT weight to body weight in a high-fat diet-induced mouse model of metabolic syndrome.Formal Name: 4-[(acetyloxy)methyl]-5-(beta-D-glucopyranosyloxy)-2aS,4aS,5S,7bS-tetrahydro-1H-2,6-dioxacyclopent[cd]inden-1-one. CAS Number: 14259-45-1. Molecular Formula: C18H22O11. Formula Weight: 414.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 5mg/mL, Ethanol: 2mg/mL, PBS (pH 7.2): 3mg/mL. lambdamax: 231 nm. SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@](C(COC(C)=O)=C[C@]3([H])OC4=O)([H])[C@@]3([H])C4=CO2)O1. InChi Code: InChI=1S/C18H22O11/c1-6(20)25-4-7-2-9-12-8(16(24)27-9)5-26-17(11(7)12)29-18-15(23)14(22)13(21)10(3-19)28-18/h2,5,9-15,17-19,21-23H,3-4H2,1H3/t9-,10+,11+,12-,13+,14-,15+,17-,18-/m0/s1. InChi Key: IBIPGYWNOBGEMH-DILZHRMZSA-N. Origin: Plant/Oldenlandia diffusa.