ASP3026

ASP3026 is an inhibitor of anaplastic lymphoma kinase (ALK, IC50s = 3.5, 10, and 5.4 nM for the wild-type, ALKF1174L, and ALKR1275Q enzymes, respectively). It is selective for ALK over a panel of 86 kinases at 1,000 nM but also inhibits c-Ros oncogene 1 (ROS1) and tyrosine kinase non-receptor 2 (TNK2, IC50s = 8.9 and 5.8 nM, respectively). ASP3026 inhibits the proliferation of Ba/F3 cells expressing nucleophosmin (NPM) or echinoderm microtubule-associated protein-like 4 (ELM4) ALK fusion proteins (IC50s = 84 and 56 nM for NPM-ALK and ELM4-ALK, respectively), as well as several Ba/F3 cells expressing NPM-ALK or ELM4-ALK mutants that are resistant to the c-Met and ALK inhibitor crizotinib (Cay-12087). It induces tumor regression in an NCI H2228 non-small cell lung cancer (NSCLC) mouse xenograft model when administered at doses of 10 and 30 mg/kg.Formal Name: N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine. CAS Number: 1097917-15-1. Molecular Formula: C29H40N8O3S. Formula Weight: 580.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 206, 268, 303 nm. SMILES: CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=NC=N4)C(OC)=C3)CC2)CC1. InChi Code: InChI=1S/C29H40N8O3S/c1-21(2)41(38,39)27-8-6-5-7-25(27)33-29-31-20-30-28(34-29)32-24-10-9-23(19-26(24)40-4)36-13-11-22(12-14-36)37-17-15-35(3)16-18-37/h5-10,19-22H,11-18H2,1-4H3,(H2,30,31,32,33,34). InChi Key: MGGBYMDAPCCKCT-UHFFFAOYSA-N.