Asiaticoside

Antibacterial - Human collagen I synthesis inducer. Anti-wrinkle activity - Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth - Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII - Anti-inflammatory. Anti-gastric ulcer - Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS, NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor - Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy - Anxiolytic - Antidepressant-like activity - Hepatoprotective effects - CYP2C19 and CYP3A4 inhibitor - Neuroprotective - Antileishmanial activity - cPLA2 and sPLA2 inhibitor.