ARV-825

Description: ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. Target: Epigenetic Reader Domain, PROTACs. Smiles: CC=1C2=C(N3C([C@H](CC(NC4=CC=C(OCCOCCOCCO CCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)C=C4)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C. References: Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18,22(6):755-63.