Artemisinic Acid

Artemisinic acid is a sesquiterpene that has been isolated from A. annua. It has been used in the synthesis of the antimalarial agent artemisinin (Cay-11816). Artemisinic acid (50-400 µM) decreases triglyceride levels and glycerol-3-phosphate dehydrogenase (GPDH) activity in human adipose tissue-derived mesenchymal stem cells (hAMSCs) in a dose-dependent manner and inhibits adipocyte differentiation when used at a concentration of 200 µM. It reduces mRNA expression and protein levels of C/EBPalpha, C/EBPdelta, and PPARgamma as well as the ratio of phosphorylated JNK to JNK in hAMSCs. Artemisinic acid also decreases C/EBPalpha and HMG-CoA reductase mRNA expression and inhibits cholesterol synthesis and melanogenesis in human epidermal melanocytes.Formal Name: 1R,2,3,4R,4aS,5,6,8aR-octahydro-4,7-dimethyl-alpha-methylene-1-naphthaleneacetic acid. CAS Number: 80286-58-4. Synonyms: Artemisic Acid. Molecular Formula: C15H22O2. Formula Weight: 234.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 16 mg/ml. lambdamax: 333 nm. SMILES: CC1=C[C@@]2([H])[C@](CC1)([H])[C@H](C)CC[C@H]2C(C(O)=O)=C. InChi Code: InChI=1S/C15H22O2/c1-9-4-6-12-10(2)5-7-13(14(12)8-9)11(3)15(16)17/h8,10,12-14H,3-7H2,1-2H3,(H,16,17)/t10-,12+,13+,14+/m1/s1. InChi Key: PLQMEXSCSAIXGB-SAXRGWBVSA-N.