ARQ 092

ARQ 092 is an allosteric, orally bioavailable, pan-Akt inhibitor (IC50s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). It is selective for Akt isoforms over a panel of 303 other kinases. ARQ 092 binds inactive Akt and prevents membrane localization and full Akt activation. It also directly inhibits the membrane-associated active form of Akt, preventing phosphorylation of downstream targets. ARQ 092 inhibits the proliferation of a wide range of cancer cells in vitro, inhibits the mutated Akt form found in Proteus syndrome, and attenuates heterotypic cell-cell interactions in a mouse model of sickle cell disease.Formal Name: 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl]-2-pyridinamine. CAS Number: 1313881-70-7. Molecular Formula: C27H24N6. Formula Weight: 432.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 344 nm. SMILES: NC1=NC=CC=C1C2=NC(C=C3)=C(N2C4=CC=C(C5(N)CCC5)C=C4)N=C3C6=CC=CC=C6. InChi Code: InChI=1S/C27H24N6/c28-24-21(8-4-17-30-24)25-32-23-14-13-22(18-6-2-1-3-7-18)31-26(23)33(25)20-11-9-19(10-12-20)27(29)15-5-16-27/h1-4,6-14,17H,5,15-16,29H2,(H2,28,30). InChi Key: HNFMVVHMKGFCMB-UHFFFAOYSA-N.