ARN25062

ARN25062 is a derivative of ARN22089, an inhibitor of the protein-protein interaction between Cdc42 and p21-activated kinase (PAK). It inhibits the proliferation of SKM28, SK-MEL-3, WM3248, and A375 melanoma cells (IC50s = 6.1, 4.6, 9.3, and 5.1 µM, respectively) and SW480 colon cancer cells (IC50 = 5.9 µM). ARN25062 (10 mg/kg) reduces tumor growth in a patient-derived xenograft (PDX) mouse model.Formal Name: 6-phenyl-2-(4-piperidinyl)-N-[3-(trifluoromethyl)phenyl]-4-pyrimidinamine. CAS Number: 3036492-85-7. Molecular Formula: C22H21F3N4. Formula Weight: 398.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: FC(F)(F)C1=CC=CC(NC2=CC(C3=CC=CC=C3)=NC(C4CCNCC4)=N2)=C1. InChi Code: InChI=1S/C22H21F3N4/c23-22(24,25)17-7-4-8-18(13-17)27-20-14-19(15-5-2-1-3-6-15)28-21(29-20)16-9-11-26-12-10-16/h1-8,13-14,16,26H,9-12H2,(H,27,28,29). InChi Key: NGGORHPZMJVKNU-UHFFFAOYSA-N.