Apigenin

Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of IkappaBalpha and down-regulates NF-kappaB levels in WEHI-231 cells. Apigenin at 5 µM is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.Formal Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 520-36-5. Synonyms: Chamomile, Flavone, NSC 83244, Versulin. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 15 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 212, 269, 334 nm. SMILES: Oc1ccc(cc1)c1cc(=O)c2c(O)cc(O)cc2o1. InChi Code: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H. InChi Key: KZNIFHPLKGYRTM-UHFFFAOYSA-N.