Apadenoson

Description: Apadenoson is a potent Adenosine A2 receptor agonist with inhibitory effects on Adenosine A3 receptors with an IC of 45 nM. Apadenoson has anti-inflammatory activity and can be used to study neurological diseases. Target: Others. Smiles: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=C(C#CC[C@@H]4CC[C@@H](C(OC)=O)CC4)N3)O[C@H](C(NCC)=O)[C@H]1O. References: Patel RA, Glover DK, Broisat A, Kabul HK, Ruiz M, Goodman NC, Kramer CM, Meerdink DJ, Linden J, Beller GA. Reduction in myocardial infarct size at 48 hours after brief intravenous infusion of ATL-146e, a highly selective adenosine A2A receptor agonist. Am J Physiol Heart Circ Physiol. 2009 Aug,297(2):H637-42. doi: 10.1152/ajpheart.00705.2008. Epub 2009 Jun 5. PubMed PMID: 19502555, PubMed Central PMCID: PMC2724215.