AP26113

AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50 12087), ceritinib (Cay-19374), and CH5424802 (Cay-18516). AP26113 blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants.Formal Name: 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine. CAS Number: 1197953-54-0. Synonyms: Brigatinib. Molecular Formula: C29H39ClN7O2P. Formula Weight: 584.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 284 nm. SMILES: COC1=C(NC2=NC=C(Cl)C(NC3=CC=CC=C3P(C)(C)=O)=N2)C=CC(N4CCC(N5CCN(C)CC5)CC4)=C1. InChi Code: InChI=1S/C29H39ClN7O2P/c1-35-15-17-37(18-16-35)21-11-13-36(14-12-21)22-9-10-24(26(19-22)39-2)33-29-31-20-23(30)28(34-29)32-25-7-5-6-8-27(25)40(3,4)38/h5-10,19-21H,11-18H2,1-4H3,(H2,31,32,33,34). InChi Key: AILRADAXUVEEIR-UHFFFAOYSA-N.