AOH1996

AOH1996 is an inhibitor of proliferating cell nuclear antigen (PCNA). It binds to PCNA in a thermal shift assay. AOH1996 (500 nM) induces apoptosis in SK-N-DZ neuroblastoma cells but not 7SMOO32 normal neural crest stem cells. It induces DNA damage in SK-N-AS neuroblastoma cells expressing wild-type DNA-directed RNA polymerase II subunit RPB1 but not in SK-N-AS cells expressing RPB1Y418A. AOH1996 (40 mg/kg) decreases tumor volume in SK-N-BE(2)-C neuroblastoma, MDA-MB-468 breast cancer, and NCI H82 small cell lung cancer mouse xenograft models.Formal Name: N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-1-naphthalenecarboxamide. CAS Number: 2089314-64-5. Molecular Formula: C26H22N2O4. Formula Weight: 426.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, Ethanol: Soluble, Methanol: Soluble. lambdamax: 222 nm. SMILES: O=C(C1=CC=CC2=C1C=CC=C2)NCC(NC3=C(C=CC=C3)OC4=CC=CC(OC)=C4)=O. InChi Code: InChI=1S/C26H22N2O4/c1-31-19-10-7-11-20(16-19)32-24-15-5-4-14-23(24)28-25(29)17-27-26(30)22-13-6-9-18-8-2-3-12-21(18)22/h2-16H,17H2,1H3,(H,27,30)(H,28,29). InChi Key: HDMONPHKMIZXDH-UHFFFAOYSA-N.