Ansatrienin A

Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-alpha-induced expression of intercellular adhesion molecule-1 (ICAM-1, IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil (Cay-14416), cisplatin (Cay-13119), bleomycin (Cay-13877), mitomycin C (Cay-11435), and 6-mercaptopurine. It is an oxidized form of ansatrienin B (Cay-21996).Formal Name: N-(cyclohexylcarbonyl)-D-alanine (5R,6E,8E,10E,13S,14R,15R,16Z)-15-hydroxy-5-methoxy-14,16-dimethyl-3,22,24-trioxo-2-azabicyclo[18.3.1]tetracosa-6,8,10,16,20,23-hexaen-13-yl ester. CAS Number: 82189-03-5. Synonyms: Mycotrienin I. Molecular Formula: C36H48N2O8. Formula Weight: 636.8. Purity: >98%. Formulation: (Request formulation change), A powder. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(N[C@H](C)C(O[C@H]([C@H](C)[C@@H](O)/C(C)=C\CCC(C(C(N1)=C2)=O)=CC2=O)C/C=C/C=C/C=C/[C@H](OC)CC1=O)=O)C3CCCCC3. InChi Code: InChI=1S/C36H48N2O8/c1-23-14-13-17-27-20-28(39)21-30(34(27)42)38-32(40)22-29(45-4)18-11-6-5-7-12-19-31(24(2)33(23)41)46-36(44)25(3)37-35(43)26-15-9-8-10-16-26/h5-7,11-12,14,18,20-21,24-26,29,31,33,41H,8-10,13,15-17,19,22H2,1-4H3,(H,37,43)(H,38,40)/b6-5+,12-7+,18-11+,23-14-/t24-,25+,29-,31-,33-/m0/s1. InChi Key: WWUVMHRJRCRFSL-UOZMSBJPSA-N.