Annonacin

Description: Annonacin is an acetogenin that promotes cytotoxicity by inhibiting the mitochondrial complex and acts as the active agent in Graviola leaf extract, inhibiting sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps[1]. Target: Others. Smiles: CCCCCCCCCC CC[C@@H](O)[C@H]1CC[C@@H](O1)[C@H](O)CCCC[C@H](O)CCCCC[C@@H](O)CC1=C[C@H](C)OC1=O. References: Yiallouris A, et al. Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways. Cell Death Dis. 2018 Jul 9,9(7):764.