Ani 9

Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM). It is selective for ANO1 over ANO2 at 10 µM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 µM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.Formal Name: 2-(4-chloro-2-methylphenoxy)-acetic acid, 2-[(2-methoxyphenyl)methylene]hydrazide. CAS Number: 356102-14-2. Molecular Formula: C17H17ClN2O3. Formula Weight: 332.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25 mg/ml. SMILES: ClC1=CC=C(OCC(N/N=C/C2=CC=CC=C2OC)=O)C(C)=C1. InChi Code: InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+. InChi Key: KDALDZRKOBJXIE-VXLYETTFSA-N.