AMTB hydrochloride

Description: AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat. Target: TRP/TRPV Channel. Smiles: Cl.Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1. References: Lin AH, Liu MH, Ko HB, Perng DW, Lee TS, Kou YR. Inflammatory Effects of Menthol vs. Non-menthol Cigarette Smoke Extract on Human Lung Epithelial Cells: A Double-Hit on TRPM8 by Reactive Oxygen Species and Menthol. Front Physiol. 2017 Apr 27,8:263. doi: 10.3389/fphys.2017.00263. eCollection 2017. PubMed PMID: 28496415, PubMed Central PMCID: PMC5406458.