Amrinone

Amrinone is an inhibitor of phosphodiesterase 3 (PDE3, IC50 = 19.5 µM). It increases developed tension and contractile force in isolated cat papillary muscle. Amrinone (1-10 mg/kg) has positive inotropic effects, increasing the rate and force of heart contraction in anesthetized and unanesthetized dogs.Formal Name: 5-amino-[3,4'-bipyridin]-6(1H)-one. CAS Number: 60719-84-8. Synonyms: WIN 40,680. Molecular Formula: C10H9N3O. Formula Weight: 187.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.3 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 202, 246, 326 nm. SMILES: NC1=CC(C2=CC=NC=C2)=CNC1=O. InChi Code: InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14). InChi Key: RNLQIBCLLYYYFJ-UHFFFAOYSA-N.