Amphotericin B (Fungizone) USP (Streptomyces)

Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death. Used in the preparation of baculoviral stocks. , Synonyms:, Abelcet, Abelecet, AmBisome, Ampho-Moronal, Amphocin, Amphozone, Apothecon, Fungilin, Fungizona, Fungizone, Halizon, LNS-AmB, NS 718, NSC 527017, CAS Number: 1397-89-3, Molecular Formula: C47H73NO17, Molecular Weight: 924.09, Appearance: Supplied as a yellow to orange powder. Identification (FAB/MS): Conforms to reference, Solubility: Soluble in DMSO and DMF/HCl, Amphotericin B is poorly soluble in water. Potency: >750ug Amphotericin B/mg, Loss on Drying: <5%, Residue upon Ignition: <0.5%, Endotoxin: <2Eu/mg, Storage: Store at 4°C. Light sensitive., , Meets or exceeds USP specifications.