Amitriptyline (hydrochloride)

Amitriptyline is a first generation tricyclic antidepressant. It inhibits serotonin (5-HT) uptake by isolated human platelets by 39 and 68% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 77% when administered at a dose of 10 mg/kg. It is also an antagonist of the 5-HT receptor subtype 5-HT2A (Ki = 20 nM), as well as histamine H1, muscarinic acetylcholine, and alpha1-adrenergic receptors (Kis = 1.1, 18, and 27 nM, respectively). Amitriptyline (5-25 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Cay-10681) or recombinant human acid sphingomyelinase. Formulations containing amitriptyline have been used in the treatment of depression and nerve pain. This product is also available as an analytical reference standard (Cay-19029, Cay-19031).Formal Name: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride. CAS Number: 549-18-8. Synonyms: NIH 10794, Ro 4-1575. Molecular Formula: C20H23N . HCl. Formula Weight: 313.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 239 nm. SMILES: CN(C)CC/C=C1C2=C(C=CC=C2)CCC3=C/1C=CC=C3.Cl. InChi Code: InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20,/h3-6,8-12H,7,13-15H2,1-2H3,1H. InChi Key: KFYRPLNVJVHZGT-UHFFFAOYSA-N.