Aminophylline

Aminophylline is a competitive and non-selective phosphodiesterase inhibitor (IC50 = 120 µM) and adenosine receptor antagonist. It is a complex of theophylline and ethylenediamine that has in vivo bronchodilator and vasodilator effects. Aminophylline suppresses maternal separation- and acetic acid administration-induced visceral hypersensitivity to colorectal distension in a rat model of irritable bowel syndrome with diarrhea (IBS-D). Aminophylline also provides renoprotection against murine renal ischemia-reperfusion injury.Formal Name: 3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione 1,2-ethanediamine (2:1). CAS Number: 317-34-0. Molecular Formula: C7H8N4O2 . 1/2C2H8N2. Formula Weight: 180.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 272 nm. SMILES: CN(C(N1C)=O)C2=C(N=CN2)C1=O.CN(C(N3C)=O)C4=C(N=CN4)C3=O.NCCN. InChi Code: InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13,3-1-2-4/h2*3H,1-2H3,(H,8,9),1-4H2. InChi Key: FQPFAHBPWDRTLU-UHFFFAOYSA-N.