Aminooxyacetic Acid (hydrochloride)

Aminooxyacetic acid is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 µM) that induces GABA accumulation in the brain. It also inhibits cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE, IC50s = 8.5 and 1.1 µM, respectively). Aminooxyacetic acid (100 mg/kg) decreases GABA-T activity, without affecting glutamic acid decarboxylase (GAD) activity, and increases GABA levels in all regions of rat brain. It also decreases GABA-T activity and increases GABA in mouse brain when administered at a dose of 13 mg/kg. Aminooxyacetic acid inhibits 3-mercaptopropionic acid-, strychnine-, and pentetrazole-induced seizures in mice (ED50s = 53, 130, and 85 mg/kg, respectively), however, it exhibits neurotoxicity in the chimney test (ED50 = 62 mg/kg) and is lethal (LD50 = 105 mg/kg) to mice.Formal Name: 2-(aminooxy)-acetic acid, hemihydrochloride. CAS Number: 2921-14-4. Synonyms: Aminooxyacetate. Molecular Formula: C2H5NO3 . 1/2HCl. Formula Weight: 109.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2mg/mL, DMSO: 5mg/mL, PBS (pH 7.2): 5mg/mL. SMILES: OC(CON)=O.OC(CON)=O.Cl. InChi Code: InChI=1S/2C2H5NO3.ClH/c2*3-6-1-2(4)5,/h2*1,3H2,(H,4,5),1H. InChi Key: KBXIJIPYZKPDRU-UHFFFAOYSA-N.