Ambroxol-d5 (hydrochloride)

Ambroxol-d5 (hydrochloride)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay38335-500 500 µg -

6 - 10 Werktage*

104,00 €
Cay38335-1 1 mg -

6 - 10 Werktage*

196,00 €
Cay38335-5 5 mg -

6 - 10 Werktage*

667,00 €
 
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol... mehr
Produktinformationen "Ambroxol-d5 (hydrochloride)"
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol (Cay-19377) by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It inhibits the voltage-gated sodium channel Nav1.2 in isolated dorsal root neurons (IC50 = 110 µM for the rat channel). Ambroxol decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM). It decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells when used at a concentration of 100 µM and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells. Ambroxol (30, 60, or 120 mg/kg) increases phenol red secretion, a marker of expectorant activity, in mice. Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.Formal Name: trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol-d5, monohydrochloride. CAS Number: 2741380-71-0. Molecular Formula: C13H13Br2D5N2O . HCl. Formula Weight: 419.6. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: NC(C(Br)=C1)=C(C=C1Br)CN[C@H](CC2([2H])[2H])CC([2H])([2H])[C@]2([2H])O.Cl. InChi Code: InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10,/h5-6,10-11,17-18H,1-4,7,16H2,1H/t10-,11-,/i3D2,4D2,11D,. InChi Key: QNVKOSLOVOTXKF-KAHSTHOTSA-N.
Schlagworte: trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-cyclohexanol-d5, monohydrochloride
Hersteller: Cayman Chemical
Hersteller-Nr: 38335

Eigenschaften

Anwendung: GC-MS, LC-MS, internal standard, quantification, sodium channel blocker
MW: 419.6 D
Formel: C13H13Br2D5N2O . HCl
Reinheit: >99% deuterated forms (d1-d5)
Format: Solid

Datenbank Information

CAS : 2741380-71-0| Passende Produkte
KEGG ID : K04842 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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