AM92016 (hydrochloride)

AM92016 is an inhibitor of delayed-rectifier potassium current (IKr, IC50 = 40 nM in isolated rabbit sinoatrial node cells). It is selective for IKr over L-type voltage-gated calcium (Cav) current and hyperpolarization-activated inward current (If) at 1 µM. AM92016 (50 nM) decreases the diastolic depolarization rate and increases cycle length and action potential duration at full repolarization in isolated rabbit sinoatrial node cells. It decreases the QT interval and increases heart rate in anesthetized guinea pigs when administered at a dose of 1 mg/kg. AM92016 (1 mg/kg) decreases the time to first arrhythmia and ventricular fibrillation in ouabain-stimulated guinea pigs.Formal Name: N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-methanesulfonamide, monohydrochloride. CAS Number: 133229-11-5. Molecular Formula: C19H24Cl2N2O4S . HCl. Formula Weight: 483.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 1 mg/ml, Ethanol: 1 mg/ml. SMILES: O=S(NC1=CC=C(C=C1)OCC(CN(CCC2=CC=C(C(Cl)=C2)Cl)C)O)(C)=O.Cl. InChi Code: InChI=1S/C19H24Cl2N2O4S.ClH/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26,/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3,1H. InChi Key: TXOARFPCQOBODS-UHFFFAOYSA-N.