Alpidem

Alpidem is an anxiolytic agent. It selectively binds to alpha1beta2gamma2 subunit-containing GABAA receptors over alpha5beta2gamma2 subunit-containing GABAA receptors in HEK293 cells (IC50s = 0.017 and >10 µM, respectively, for the recombinant rat receptors). Alpidem also binds to the GABAA/benzodiazepine receptor complex and translocator protein 18 kDa (TSPO) with IC50 values of 0.028 and 0.0079 µM, respectively. It reduces marble burying in mice, indicating anxiolytic activity, with a minimum effective dose (MED) of 10 mg/kg. Unlike the benzodiazepine alprazolam, alpidem does not induce sedation in mice when administered at doses up to 2 mg/kg. Formulations containing alpidem have previously been used in the treatment of generalized anxiety disorder.Formal Name: 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide. CAS Number: 82626-01-5. Molecular Formula: C21H23Cl2N3O. Formula Weight: 404.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: O=C(CC1=C(C2=CC=C(C=C2)Cl)N=C3C=CC(Cl)=CN31)N(CCC)CCC. InChi Code: InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3. InChi Key: JRTIDHTUMYMPRU-UHFFFAOYSA-N.