alpha-Cyano-4-hydroxycinnamic Acid

alpha-Cyano-4-hydroxycinnamic acid (alpha-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 = 1.5 µM). It is commonly used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications.Formal Name: 2-cyano-3-(4-hydroxyphenyl)-2-propenoic acid. CAS Number: 28166-41-8. Synonyms: CHC, alpha-CHCA, NSC 173138. Molecular Formula: C10H7NO3. Formula Weight: 189.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): 100 µg/ml. lambdamax: 242, 344 nm. SMILES: OC1=CC=C(/C=C(C(O)=O)\C#N)C=C1. InChi Code: InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+. InChi Key: AFVLVVWMAFSXCK-VMPITWQZSA-N.