(-)-alpha-Bisabolol

(-)-alpha-Bisabolol is a sesquiterpene alcohol that has been found in the essential oils of several aromatic plants, including C. sativa, C. indica, and C. sativa/C. indica hybrid strains, with diverse biological activities. It inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 µg/ml, respectively). It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 µM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 µM in L929 cells. In vivo, (-)-alpha-bisabolol (200 mg/kg) reduces parasite load in the liver and spleen in a mouse model of visceral leishmaniasis. (-)-alpha-Bisabolol (200 mg/kg) reduces the size of ethanol-induced lesions, decreases malondialdehyde (MDA) production, and increases superoxide dismutase (SOD) activity in gastric mucosa in mice. It also decreases serotonin-, carrageenan-, and dextran-, but not histamine-, induced paw edema as well as acetic-acid induced writhing and paw-licking time in the formalin test in mice, indicating anti-inflammatory and antinociceptive activity.Formal Name: (alphaS,1S)-alpha,4-dimethyl-alpha-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-methanol. CAS Number: 23089-26-1. Molecular Formula: C15H26O. Formula Weight: 222.4. Purity: >90%. Formulation: (Request formulation change), A neat oil. Solubility: Ethanol: Soluble. SMILES: CC1=CC[C@]([C@](O)(C)CC/C=C(C)\C)([H])CC1. InChi Code: InChI=1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m1/s1. InChi Key: RGZSQWQPBWRIAQ-CABCVRRESA-N.